OUR SCIENCE

PIPELINES

t_brainoriented.png

To bring innovative new therapeutics, AIMEDBIO is building a multi-disciplinary brain portfolio.

t_examplepipelines.png

1

2

3

4

AMB302 l Brain tumor targeting ADC

Distinct epitope & novel function

① ADC binding to receptor expressed on target cell

② ADC-bound receptor internalization

③ Receptor and antibody degradation

​④ Toxin release to kill target cell

AMB401 l Tumor targeting toxin

Highly potent, brain tumor-sensitive

① Toxin integration into tumor cell

② DNA damage leads to cell death

Untitled (5).png

AMB001 & 011 l immune checkpoint agonist

Designed to activate an immune receptor expressed on myeloid cells. By activating the receptor, AMB001 suppresses myeloid cells, thereby protecting healthy neurons through:

① Inhibition of inflammation

② Phagocytotic clearance of neurotoxic molecules