OUR SCIENCE

PUBLICATIONS

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A strong track record of publication in the area of brain disease and big data

2020

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BRAIN IMMUNE MODULATION

Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchy-mal glioblastoma

Genome Biology

August 2020

PHARMACOGENOMIC LANDSCAPE

Comprehensive pharmacogenomic characterization of gastric cancer

 

 

Genome Medicine

December 2020

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PHARMACO-PROTEOMIC LANDSCAPE

Integrated pharmaco-proteogeno-mics defines two subgroups in iso-citrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities

Genome Medicine

December 2020

2019

TUMOR PROGRESSION MECHANISM

PIP4K2A as a negative regulator of PI3K in pTEN-deficient glioblastoma

 

 

Journal of Experimental Medicine

May 2019

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TUMOR EVOLUTION & CHROMOSOMAL ELEMENTS

Longitudinal molecular trajectories of diffuse glioma in adults

 

 

Nature

November 2019

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PHARMACOGENOMIC LANDSCAPE

Pharmacogenomic analysis of patient-derived tumor cells in gynecologic cancers

Genome Biology

November 2019

2018

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TUMOR EVOLUTION & CHROMOSOMAL ELEMENTS

Discordant inheritance of chromo-somal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

Nature Genetics

April 2018

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TUMOR PROGRESSION MECHANISM

Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors

Cancer Cell

July 2018

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TUMOR MESENCHYMAL TRANSITION

A tension-mediated glycocalyx–integrin feedback loop promotes mesenchymal-like glioblastoma

 

Nature Cell Biology

September 2018

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PHARMACOGENOMIC LANDSCAPE

Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy

Nature Genetics

September 2018

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MUTATIONAL LANDSCAPE IN BRAIN TUMOR

Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor

Cell

November 2018

2015~2017

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TUMOR EVOLUTION

Spatiotemporal Evolution of the Primary Glioblastoma Genome

Cancer Cell

September 2015

TUMOR EVOLUTION MODEL

Clonal evolution of glioblastoma under therapy

Nature Genetics

July 2016

TUMOR HETEROGENEITY & DRUG SELECTION

Spatiotemporal genomic architecture informs precision oncology in glioblastoma

Nature Genetics

March 2017

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TUMOR EVOLUTION & IMMUNE SIGNATURES

Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment

Cancer Cell

July 2017